You can tell mysqld to run in ANSI mode with the --ansi startup option. Running the server in ANSI mode is the same as starting it with the following options:

--transaction-isolation=SERIALIZABLE --sql-mode=ANSI

You can achieve the same effect at runtime by executing these two statements:

SET GLOBAL TRANSACTION ISOLATION LEVEL SERIALIZABLE;
SET GLOBAL sql_mode = 'ANSI';

You can see that setting the sql_mode system variable to 'ANSI' enables all SQL mode options that are relevant for ANSI mode as follows:

mysql> SET GLOBAL sql_mode='ANSI';
mysql> SELECT @@global.sql_mode;
        -> 'REAL_AS_FLOAT,PIPES_AS_CONCAT,ANSI_QUOTES,IGNORE_SPACE,ANSI'

Running the server in ANSI mode with --ansi is not quite the same as setting the SQL mode to 'ANSI'. The --ansi option affects the SQL mode and also sets the transaction isolation level. Setting the SQL mode to 'ANSI' has no effect on the isolation level.

See Section 5.1.2, “Server Command Options”, and Section 1.8.2, “Selecting SQL Modes”.