Because each InnoDB table has a primary key (whether you request one or not), specify a set of primary key columns for each table, columns that are used in the most important and time-critical queries.

Do not specify too many or too long columns in the primary key, because these column values are duplicated in each secondary index.

Do not create a separate secondary index for each column, because each query can only make use of one index. Indexes on rarely tested columns or columns with only a few different values might not be helpful for any queries. If you have many queries for the same table, testing different combinations of columns, try to create a small number of concatenated indexes rather than a large number of single-column indexes. If an index contains all the columns needed for the result set (known as a covering index), the query might be able to avoid reading the table data at all.

If an indexed column cannot contain any NULL values, declare it as NOT NULL when you create the table. The optimizer can better determine which index is most effective to use for a query, when it knows whether each column contains NULL values or not.

If you often have recurring queries for tables that are not updated frequently, enable the query cache:

[mysqld]
query_cache_type = 1
query_cache_size = 10M